The ISHSR was established in December 2008 to serve as a non-profit organization to promote education, basic and translational research on the cells of the hepatic sinusoid including liver parenchymal cells. It promotes science on cell and molecular biology of each cell type and cross-talk among these cell types in health and disease during an entire life span.

The ISHSR supports the Liver Sinusoid Meeting, formally called International Kupffer Cell Symposium (1977-1988) and International Symposium on Cells of the Hepatic Sinusoid: ISCHS (1990-2008).

The ISHSR currently has more than 150 members from 20 nations who are primarily interested in hepatic sinusoidal cells such as sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, cholangiocytes, NK cells, and hepatocytes.